Understanding powder behaviour is essential for optimising bulk solids production processes and developing high-quality products. This webinar introduces the challenges associated with predicting powder flowability and discusses how quantifying powder behaviour can benefit process performance.
Currently the measure for quality in pharmaceutical wet-milling unit operations have been focused on size reduction and particle size distribution results. It has been shown that particle shape is equally important to be monitored and controlled during the process. Shape has direct influence on physical character and can cause mechanical interlocking and affect flowability. Dissolution character, compression and friability are greatly affected by shape.
Granulation is often employed during the production of pharmaceutical formulations for oral solid dose delivery. Due to the potency of most APIs the quantity required per capsule is extremely small, therefore a granulation step is often required to ensure content uniformity.