Biomarker für aggressives Tumorwachstum

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Literatur

[1] S. Bergmann et al.: YB-1 Provokes Breast Cancer through the Induction of Chromosomal Instability That Emerges from Mitotic Failure and Centrosome Amplification, Cancer Research 65, 4078 - 4087 (2005)

[2] M. Kuwano et al.: The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1) and angiogenesis-related factors in human malignancies, Cancer Science 94, 9 - 14 (2003)

[3] R. C. Bargou et al.: Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression, Nature Medicine 3, 447 - 450 (1997)

[4] T. Fujita et al.: Increased Nuclear Localization of Transcription Factor Y-Box Binding Protein 1 Accompanied by Up-Regulation of P-glycoprotein in Breast Cancer Pretreated with Paclitaxel, Clinical Cancer Research 11, 8837 - 8844 (2005)

[5] M. Janz et al.: Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, UPA and PAI-1., International journal of cancer 97, 278 - 282 (2002)

[6] R. Yao et al.: Differentially expressed genes associated with mouse lung tumor progression, Oncogene 21, 5814 – 5821 (22. August 2002)

[7] C. Gessner et al.: Nuclear YB-1 expression as a negative prognostic marker in nonsmall cell lung cancer, European Respiratory Journal 23, 14 - 19 (2004)

[8] K. Shibahara et al.: Nuclear Expression of the Y-Box Binding Protein, YB-1, as a Novel Marker of Disease Progression in Non-Small Cell Lung Cancer, Clinical Cancer Research 7, 3151 – 3155 (Oktober 2001)

[9] P. Giménez-Bonafé et al.: YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity., The Prostate 59, 337 - 349 (2004)

[10] T. Kamura et al.: Is nuclear expression of Y box-binding protein-1 a new prognostic factor in ovarian serous adenocarcinoma?, Cancer 85, Pages 2450 - 2454 (2000)

[11] X. Huang et al.: Co-expression of Y box-binding protein-1 and P-glycoprotein as a prognostic marker for survival in epithelial ovarian cancer, Gynecologic Oncology 93, 287 - 291 (2004)

*Dr. T. Hiddemann, antibodies-online GmbH, 52074 Aachen

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